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NishMath - #ai
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Google DeepMind has launched AlphaGenome, a new deep learning framework designed to predict the regulatory consequences of DNA sequence variations. This AI model aims to decode how mutations affect non-coding DNA, which makes up 98% of the human genome, potentially transforming the understanding of diseases. AlphaGenome processes up to one million base pairs of DNA at once, delivering predictions on gene expression, splicing, chromatin accessibility, transcription factor binding, and 3D genome structure.
AlphaGenome stands out by comprehensively predicting the impact of single variants or mutations, especially in non-coding regions, on gene regulation. It uses a hybrid neural network that combines convolutional layers and transformers to digest long DNA sequences. The model addresses limitations in earlier models by bridging the gap between long-sequence input processing and nucleotide-level output precision, unifying predictive tasks across 11 output modalities and handling thousands of human and mouse genomic tracks. This makes AlphaGenome one of the most comprehensive sequence-to-function models in genomics. The AI tool is available via API for non-commercial research to advance scientific research and is planned to be released to the general public in the future. In performance tests, AlphaGenome outperformed or matched the best external models on 24 out of 26 variant effect prediction benchmarks. According to DeepMind's Vice President for Research Pushmeet Kohli, AlphaGenome unifies many different challenges that come with understanding the genome. The model can help researchers identify disease-causing variants and better understand genome function and disease biology, potentially driving new biological discoveries and the development of new treatments. Recommended read:
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Steve Vandenberg@Microsoft Security Blog
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Microsoft is making significant strides in AI and data security, demonstrated by recent advancements and reports. The company's commitment to responsible AI is highlighted in its 2025 Responsible AI Transparency Report, detailing efforts to build trustworthy AI technologies. Microsoft is also addressing the critical issue of data breach reporting, offering solutions like Microsoft Data Security Investigations to assist organizations in meeting stringent regulatory requirements such as GDPR and SEC rules. These initiatives underscore Microsoft's dedication to ethical and secure AI development and deployment across various sectors.
AI's transformative potential is being explored in higher education, with Microsoft providing AI solutions for creating AI-ready campuses. Institutions are focusing on using AI for unique differentiation and innovation rather than just automation and cost savings. Strategies include establishing guidelines for responsible AI use, fostering collaborative communities for knowledge sharing, and partnering with technology vendors like Microsoft, OpenAI, and NVIDIA. Comprehensive training programs are also essential to ensure stakeholders are proficient with AI tools, promoting a culture of experimentation and ethical AI practices. Furthermore, Microsoft Research has achieved a breakthrough in computational chemistry by using deep learning to enhance the accuracy of density functional theory (DFT). This advancement allows for more reliable predictions of molecular and material properties, accelerating scientific discovery in fields such as drug development, battery technology, and green fertilizers. By generating vast amounts of accurate data and using scalable deep-learning approaches, the team has overcome limitations in DFT, enabling the design of molecules and materials through computational simulations rather than relying solely on laboratory experiments. Recommended read:
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@www.marktechpost.com
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Google has unveiled a new AI model designed to forecast tropical cyclones with improved accuracy. Developed through a collaboration between Google Research and DeepMind, the model is accessible via a newly launched website called Weather Lab. The AI aims to predict both the path and intensity of cyclones days in advance, overcoming limitations present in traditional physics-based weather prediction models. Google claims its algorithm achieves "state-of-the-art accuracy" in forecasting cyclone track and intensity, as well as details like formation, size, and shape.
The AI model was trained using two extensive datasets: one describing the characteristics of nearly 5,000 cyclones from the past 45 years, and another containing millions of weather observations. Internal testing demonstrated the algorithm's ability to accurately predict the paths of recent cyclones, in some cases up to a week in advance. The model can generate 50 possible scenarios, extending forecast capabilities up to 15 days. This breakthrough has already seen adoption by the U.S. National Hurricane Center, which is now using these experimental AI predictions alongside traditional forecasting models in its operational workflow. Google's AI's ability to forecast up to 15 days in advance marks a significant improvement over current models, which typically provide 3-5 day forecasts. Google made the AI accessible through a new website called Weather Lab. The model is available alongside two years' worth of historical forecasts, as well as data from traditional physics-based weather prediction algorithms. According to Google, this could help weather agencies and emergency service experts better anticipate a cyclone’s path and intensity. Recommended read:
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@www.marktechpost.com
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Apple researchers are challenging the perceived reasoning capabilities of Large Reasoning Models (LRMs), sparking debate within the AI community. A recent paper from Apple, titled "The Illusion of Thinking," suggests that these models, which generate intermediate thinking steps like Chain-of-Thought reasoning, struggle with fundamental reasoning tasks. The research indicates that current evaluation methods relying on math and code benchmarks are insufficient, as they often suffer from data contamination and fail to assess the structure or quality of the reasoning process.
To address these shortcomings, Apple researchers introduced controllable puzzle environments, including the Tower of Hanoi, River Crossing, Checker Jumping, and Blocks World, allowing for precise manipulation of problem complexity. These puzzles require diverse reasoning abilities, such as constraint satisfaction and sequential planning, and are free from data contamination. The Apple paper concluded that state-of-the-art LRMs ultimately fail to develop generalizable problem-solving capabilities, with accuracy collapsing to zero beyond certain complexities across different environments. However, the Apple research has faced criticism. Experts, like Professor Seok Joon Kwon, argue that Apple's lack of high-performance hardware, such as a large GPU-based cluster comparable to those operated by Google or Microsoft, could be a factor in their findings. Some argue that the models perform better on familiar puzzles, suggesting that their success may be linked to training exposure rather than genuine problem-solving skills. Others, such as Alex Lawsen and "C. Opus," argue that the Apple researchers' results don't support claims about fundamental reasoning limitations, but rather highlight engineering challenges related to token limits and evaluation methods. Recommended read:
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Carl Franzen@AI News | VentureBeat
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Mistral AI has launched its first reasoning model, Magistral, signaling a commitment to open-source AI development. The Magistral family features two models: Magistral Small, a 24-billion parameter model available with open weights under the Apache 2.0 license, and Magistral Medium, a proprietary model accessible through an API. This dual release strategy aims to cater to both enterprise clients seeking advanced reasoning capabilities and the broader AI community interested in open-source innovation.
Mistral's decision to release Magistral Small under the permissive Apache 2.0 license marks a significant return to its open-source roots. The license allows for the free use, modification, and distribution of the model's source code, even for commercial purposes. This empowers startups and established companies to build and deploy their own applications on top of Mistral’s latest reasoning architecture, without the burdens of licensing fees or vendor lock-in. The release serves as a powerful counter-narrative, reaffirming Mistral’s dedication to arming the open community with cutting-edge tools. Magistral Medium demonstrates competitive performance in the reasoning arena, according to internal benchmarks released by Mistral. The model was tested against its predecessor, Mistral-Medium 3, and models from Deepseek. Furthermore, Mistral's Agents API's Handoffs feature facilitates smart, multi-agent workflows, allowing different agents to collaborate on complex tasks. This enables modular and efficient problem-solving, as demonstrated in systems where agents collaborate to answer inflation-related questions. Recommended read:
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Mark Tyson@tomshardware.com
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OpenAI has recently launched its newest reasoning model, o3-pro, making it available to ChatGPT Pro and Team subscribers, as well as through OpenAI’s API. Enterprise and Edu subscribers will gain access the following week. The company touts o3-pro as a significant upgrade, emphasizing its enhanced capabilities in mathematics, science, and coding, and its improved ability to utilize external tools.
OpenAI has also slashed the price of o3 by 80% and o3-pro by 87%, positioning the model as a more accessible option for developers seeking advanced reasoning capabilities. This price adjustment comes at a time when AI providers are competing more aggressively on both performance and affordability. Experts note that evaluations consistently prefer o3-pro over the standard o3 model across all categories, especially in science, programming, and business tasks. O3-pro utilizes the same underlying architecture as o3, but it’s tuned to be more reliable, especially on complex tasks, with better long-range reasoning. The model supports tools like web browsing, code execution, vision analysis, and memory. While the increased complexity can lead to slower response times, OpenAI suggests that the tradeoff is worthwhile for the most challenging questions "where reliability matters more than speed, and waiting a few minutes is worth the tradeoff.” Recommended read:
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